|
KMID : 1035620150030020099
|
|
Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 2 p.99 ~ p.104
|
|
|
Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction
|
|
유정섭:You Jueng-Sup
최원복:Choi Won-Bok/이윤영:Yi Yoon-Young/정수인:Jeong Soo-In/송준섭:Song Joon-Sup/양승:Yang Seong/황일태:Hwang Il-Tae/이하백:Lee Ha-Baik/백혜성:Baek Hey-Sung
|
|
|
Abstract
|
|
|
Purpose: Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that serum leptin levels correlate with (EIB) in children with asthma. The aim of this study was to address the relationship between plasma sPLA2/leptin levels and EIB.
Methods: Sixty-seven prepubertal children between the ages of 6 and 10 years were included in the study. They were asthmatics with EIB (n=25), asthmatics without EIB (n=21), and healthy subjects (n=21). We measured the plasma sPLA2 and leptin levels. We also performed pulmonary function tests at baseline, after bronchodilator inhalation, and after exercise.
Results: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in those without and control subjects. In addition, sPLA2 levels were significantly correlated with body mass index (Speraman correlation coefficient r=0.343, P=0.023) and leptin levels (partial correlation coefficient r=318, P=0.033). The maximum decrease in % forced expiratory volume in 1 second after exercise was significantly correlated with both PLA2 levels (r=0.301, P=0.041) and leptin levels (r=0.346, P=0.018).
Conclusion: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in asthmatics without EIB and control subjects. In addition, sPLA2 levels were significantly correlated with leptin levels and EIB in asthmatic children.
|
|
|
KEYWORD
|
|
|
Secreted phospholipase A2, Leptin, Exercise-induced bronchoconstriction, Asthma, Child
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|